MovDisordV3, Main, Exploration, bibRecord, 001178

Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease

Identifieur interne : 001178 ( Main/Exploration ); précédent : 001177; suivant : 001179

Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease

Auteurs : Lonneke M. L. De Lau [Pays-Bas] ; Dagmar Verbaan [Pays-Bas] ; Johan Marinus [Pays-Bas] ; Peter Heutink [Pays-Bas] ; Jacobus J. Van Hilten [Pays-Bas]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0106493

Descripteurs français

Pascal (Inist)
- Dyskinésie, Maladie de Parkinson, Pathologie du système nerveux, Catechol O-methyltransferase, Facteur risque.

English descriptors

KwdEn :
- Catechol O-methyltransferase, Dyskinesia, Nervous system diseases, Parkinson disease, Risk factor.

Abstract

Background: The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. Results: The A-allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow-up, in a dose-dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07-4.06] and 2.81 [CI, 1.43-5.54], respectively). Conclusions: This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Catechol O-methyltransferase</term>
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<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Risk factor</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term>
<term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">Background: The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. Results: The A-allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow-up, in a dose-dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07-4.06] and 2.81 [CI, 1.43-5.54], respectively). Conclusions: This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD.</div>
</front>
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<name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J." last="Van Hilten">Jacobus J. Van Hilten</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease

Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri